8-9.Kind of wrinkle:Big　wrinkle
	The wrinkle that the ditch on the surface of the skin becomes deep with the age is said. Collagen and Erastin in the corium layer become and the wrinkle becomes deep from decrease of the number also of degeneration and hyaluronic acid. In addition, deep wrinkle can be done by fat's the muscle's becoming weak, becomeing thin, and attaching there. There are a wrinkle of amount and a hollow part etc. of a corners of the mouth and the above eyelid about a big wrinkle assuming that it is typical.